Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592134 | 0.88 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL28695544 | 0.86 | NOS2 (0.36) | NOS2NOS3NOS1PRCPDPP4 | |
| Hydrochloric Acid SCHEMBL6026726 | 0.86 | NOS2 (0.36) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL28992550 | 0.86 | NOS2 (0.38) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL7378973 | 0.85 | NOS2 (0.35) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL15210886 | 0.85 | NOS2 (0.39) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL27646576 | 0.85 | NOS2 (0.39) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL499450 | 0.85 | NOS2 (0.39) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL20839948 | 0.85 | NOS2 (0.35) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL3236621 | 0.84 | NOS2 (0.36) | NOS2NOS3NOS1PRCPDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400303-A1 | Markers of Oocyte quality | UNIVERSITY COLLEGE DUBLIN (IE) | 2011-12-28 | — | — | EP | disclosed |
| EP-0350138-B1 | Processes for preparing phosphonyl hydroxyacyl prolines | SQUIBB & SONS INC (US) | 1994-10-19 | — | — | EP | disclosed |
| EP-0253179-B1 | A-ACYLAMINO AMINOALKYL PHOPHONATE ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1991-12-04 | — | — | EP | disclosed |
| EP-0350138-A2 | Processes for preparing phosphonyl hydroxyacyl prolines | E.R. SQUIBB & SONS, INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| US-4849414-A | HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0097534-B1 | PHOSPHONYL HYDROXYACYL AMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES | E.R. Squibb & Sons, Inc. (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4745196-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1988-05-17 | — | — | US | disclosed |
| EP-0253179-A2 | A-acylamino aminoalkyl phophonate angiotensin converting enzyme inhibitors | E.R. Squibb & Sons, Inc. (US) | 1988-01-20 | — | — | EP | disclosed |
| EP-0249445-A2 | Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-12-16 | — | — | EP | disclosed |
| US-4703043-A | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive | E. R. SQUIBB & SONS, INC. (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0239109-A2 | Phosphonate angiotensin converting enzyme inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-09-30 | — | — | EP | disclosed |
| EP-0229520-A1 | Orally active phosphonyl hydroxyacyl prolines and processes for preparing phosphonyl hydroxyacyl prolines | E.R. Squibb & Sons, Inc. (US) | 1987-07-22 | — | — | EP | disclosed |
| US-4616005-A | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives | E. R. SQUIBB & SONS, INC. (US) | 1986-10-07 | — | — | US | disclosed |
| US-4452790-A | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives | E. R. SQUIBB & SONS, INC. (US) | 1984-06-05 | — | — | US | disclosed |