Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 4/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379805 | 0.87 | NOS2 (0.33) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL9592134 | 0.86 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL1740647 | 0.85 | NOS2 (0.36) | NOS2NOS3NOS1PRCPDPP4 | |
| Hydrochloric Acid SCHEMBL6026726 | 0.85 | NOS2 (0.36) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL28695544 | 0.85 | NOS2 (0.36) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL27646576 | 0.83 | NOS2 (0.39) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL20839948 | 0.83 | NOS2 (0.35) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL499450 | 0.83 | NOS2 (0.39) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL15210886 | 0.83 | NOS2 (0.39) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL11434311 | 0.83 | CYP3A4 (0.33) | NOS2NOS3NOS1PRCPDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4745124-A | THIO/ESTER PEPTIDES | UNIVERSITY OF MIAMI (US) | 1988-05-17 | — | — | US | disclosed |
| US-4692459-A | SULFUR CONTAINING AMINO ACID DERIVATIVES, ANGIOTENSIN INHIBITOR | UNIVERSITY OF MIAMI (US) | 1987-09-15 | — | — | US | disclosed |
| EP-0035383-B1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | UNIVERSITY OF MIAMI (US) | 1984-05-30 | — | — | EP | disclosed |
| EP-0035383-A1 | Angiotensin converting enzyme inhibitors | UNIVERSITY OF MIAMI (US) | 1981-09-09 | — | — | EP | disclosed |
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4046889-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION | E. R. SQUIBB & SONS, INC. (US) | 1977-09-06 | — | — | US | disclosed |