Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 3/20 | 0.51 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14478824 | 0.88 | PDE10A (0.66) | TSHRPDE10ADHODHMEN1KMT2A | |
| SCHEMBL2373562 | 0.83 | PDE10A (0.74) | MAPTKDM4ETSHRPDE10ADHODH | |
| SCHEMBL2373101 | 0.79 | MAPT (0.69) | MAPTKDM4ETSHRPDE10ADHODH | |
| SCHEMBL4505560 | 0.75 | NPC1 (0.51) | MAPTKDM4EMEN1KMT2ATP53 | |
| SCHEMBL4514198 | 0.75 | NPC1 (0.51) | MAPTKDM4EMEN1KMT2ATP53 | |
| SCHEMBL3322283 | 0.74 | FABP4 (0.69) | KDM4ETP53 | |
| SCHEMBL28874732 | 0.73 | NPC1 (0.55) | MAPTKDM4EMEN1KMT2ATP53 | |
| SCHEMBL4502808 | 0.73 | NPC1 (0.50) | MAPTKDM4EMEN1KMT2ATP53 | |
| SCHEMBL29387699 | 0.73 | MAPT (0.61) | MAPTKDM4ETSHRPDE10ADHODH | |
| SCHEMBL28027244 | 0.72 | PTGS1 (0.54) | MAPTKDM4ETSHRPDE10ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004035-A1 | 2-ARYL-4-QUINOLINECARBOXAMIDE DERIVATIVES FOR TREATING THYROID DISEASES | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-01-07 | — | — | WO | disclosed |