Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | DHODH | Q02127 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TACR3 | P29371 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PTGFR | P43088 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373562 | 0.88 | PDE10A (0.74) | MAPTKDM4EKMT2ADHODHHTT | |
| SCHEMBL2372674 | 0.87 | PDE10A (0.73) | MAPTKDM4EKMT2AMEN1DHODH | |
| SCHEMBL4879045 | 0.86 | DHODH (0.71) | MAPTKDM4EKMT2AMEN1DHODH | |
| SCHEMBL2373281 | 0.85 | KDM4E (0.55) | MAPTKDM4EKMT2AMEN1DHODH | |
| SCHEMBL2373011 | 0.83 | DHODH (0.58) | MAPTKDM4EKMT2AMEN1DHODH | |
| SCHEMBL2373092 | 0.79 | KDM4E (0.56) | MAPTKDM4EKMT2AMEN1DHODH | |
| SCHEMBL29387699 | 0.79 | MAPT (0.61) | MAPTKDM4EKMT2AMEN1DHODH | |
| SCHEMBL2373435 | 0.79 | DHODH (0.57) | MAPTKDM4EDHODHHTTPLA2G2A | |
| SCHEMBL17413271 | 0.79 | MAPT (0.52) | MAPTKDM4EKMT2AMEN1DHODH | |
| SCHEMBL5945348 | 0.77 | DHODH (0.63) | MAPTKDM4EDHODHPDE10ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |