SCHEMBL174161

SCHEMBL174161

O=C(O)Oc1nn(Cc2ccccc2F)c2ncccc12

nearest known ligand 0.53

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.53
KCNH2 Q12809 1/20 0.53
ATM Q13315 1/20 0.48
PDE5A O76074 14/20 0.47
MAPT P10636 1/20 0.47
GUCY1A1 Q02108 1/20 0.42
GUCY1B1 Q02153 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3953305 0.86 PDE5A (0.54) ADORA3KCNH2ATMPDE5AGUCY1A1
SCHEMBL6762615 0.83 MAPT (0.47) ADORA3KCNH2ATMPDE5AMAPT
SCHEMBL174160 0.82 ATM (0.54) ADORA3KCNH2ATMPDE5AMAPT
SCHEMBL6762762 0.79 MAPT (0.50) ADORA3KCNH2ATMPDE5AMAPT
SCHEMBL4937101 0.79 ATM (0.53) ADORA3KCNH2ATMPDE5AMAPT
SCHEMBL4929205 0.79 ATM (0.53) ADORA3KCNH2ATMPDE5AMAPT
SCHEMBL175370 0.79 ATM (0.53) ADORA3KCNH2ATMPDE5AMAPT
SCHEMBL6224401 0.78 PDE5A (0.47) ADORA3KCNH2PDE5AGUCY1A1GUCY1B1
SCHEMBL174575 0.77 PDE5A (0.58) ADORA3KCNH2PDE5AGUCY1A1GUCY1B1
SCHEMBL175344 0.77 ADORA3 (0.63) ADORA3KCNH2PDE5AGUCY1A1GUCY1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017121700-A1 1,3-DISUBSTITUTED 1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AND USE THEREOF AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-07-20 WO disclosed
EP-2611802-B1 BICYCLIC AZA-HETEROCYCLES AND THEIR USE BAYER IP GMBH (DE) 2016-02-24 EP disclosed
EP-2611802-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF Bayer Intellectual Property GmbH (DE) 2013-07-10 EP disclosed
WO-2012028647-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-03-08 WO disclosed
EP-2013205-A1 HETEROCYCLIC SUBSTITUTED, ANELLATED PYRAZOLE DERIVATIVE AND ITS USES Bayer HealthCare AG (DE) 2009-01-14 EP disclosed
WO-2007124854-A1 HETEROCYCLIC SUBSTITUTED, ANELLATED PYRAZOLE DERIVATIVE AND ITS USES BAYER HEALTHCARE AG (DE) 2007-11-08 WO disclosed