Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3953305 | 0.92 | PDE5A (0.54) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL6227911 | 0.84 | PTGDR2 (0.48) | PDE5A | |
| SCHEMBL6068569 | 0.84 | ELANE (0.52) | PDE5AADORA3KCNH2 | |
| SCHEMBL174161 | 0.78 | ADORA3 (0.53) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL6068600 | 0.76 | CFD (0.49) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL2883538 | 0.75 | PDE5A (0.53) | PDE5AADORA3KCNH2 | |
| SCHEMBL9913926 | 0.74 | PDE5A (0.55) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140289 | 0.74 | ADORA3 (0.45) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL9913937 | 0.74 | PDE5A (0.54) | PDE5AADORA3KCNH2 | |
| SCHEMBL327073 | 0.73 | PDE5A (0.44) | PDE5AADORA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509228-B1 | DERIVATIVES OF 2-(1-BENZYL-1H-PYRAZOLO (3, 4-B)PYRIDINE-3YL) -5-(4-PYRIDINYL)-4-PYRIMIDINE AMINE AND THE USE THEREOF AS GUANYLATE CYCLASE STIMULATORS | BAYER HEALTHCARE AG (DE) | 2005-12-14 | — | — | EP | disclosed |
| EP-1509228-A1 | DERIVATIVES OF 2-(1-BENZYL-1H-PYRAZOLO (3, 4-B)PYRIDINE-3YL) -5-(4-PYRIDINYL)-4-PYRIMIDINE AMINE AND THE USE THEREOF AS GUANYLATE CYCLASE STIMULATORS | Bayer HealthCare AG (DE) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003097063-A1 | DERIVATIVES OF 2-(1-BENZYL-1H-PYRAZOLO (3, 4-B)PYRIDINE-3YL) -5-(4-PYRIDINYL)-4-PYRIMIDINE AMINE AND THE USE THEREOF AS GUANYLATE CYCLASE STIMULATORS | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |