Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17423123 | 0.90 | SCN9A (0.60) | SCN9ASCN5A | |
| SCHEMBL17423124 | 0.90 | SCN9A (0.60) | SCN9ASCN5A | |
| SCHEMBL17428285 | 0.90 | SCN9A (0.58) | SCN9ASCN5A | |
| SCHEMBL17423135 | 0.90 | SCN9A (0.58) | SCN9ASCN5A | |
| SCHEMBL17423142 | 0.85 | SCN9A (0.62) | SCN9ASCN5A | |
| SCHEMBL17423144 | 0.85 | SCN9A (0.62) | SCN9ASCN5A | |
| SCHEMBL17428729 | 0.84 | SCN9A (0.53) | SCN9ASCN5A | |
| SCHEMBL21075466 | 0.83 | ALDH1A1 (0.52) | SCN9ASCN5A | |
| SCHEMBL15536889 | 0.82 | SCN9A (0.56) | SCN9ASCN5A | |
| SCHEMBL21075573 | 0.82 | SCN9A (0.51) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007534-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-01-14 | — | — | WO | disclosed |