Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 15/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.77 |
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.77 |
| ▸ | HDAC11 | Q96DB2 | 15/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.77 |
| ▸ | HDAC9 | Q9UKV0 | 15/20 | 0.77 |
| ▸ | HDAC5 | Q9UQL6 | 15/20 | 0.77 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.77 |
| ▸ | TUBB | P07437 | 8/20 | 0.77 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.77 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.77 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.77 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.77 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.77 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.77 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144150 | 0.87 | HDAC8 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1367877 | 0.87 | HDAC8 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2143790 | 0.87 | HDAC8 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1367274 | 0.79 | HDAC8 (0.66) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5356201 | 0.79 | HDAC3 (0.66) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5464107 | 0.79 | HDAC8 (0.66) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11993876 | 0.78 | HDAC6 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16566438 | 0.77 | HDAC3 (0.64) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4896903 | 0.76 | HDAC8 (1.00) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1366285 | 0.76 | HDAC3 (0.61) | HDAC8HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966078-A2 | Inhibitors of histone deacetylase | MethylGene Inc. (CA) | 2016-01-13 | — | — | EP | disclosed |