Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591133 | 0.87 | MET (0.47) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL23128042 | 0.85 | MET (0.47) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL16882542 | 0.84 | MET (0.46) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591016 | 0.81 | MET (0.47) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL22475682 | 0.80 | MET (0.42) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12487863 | 0.79 | MET (0.77) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL19261423 | 0.79 | MET (0.65) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL16882509 | 0.78 | MET (0.45) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL21167685 | 0.77 | MET (0.48) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL16882492 | 0.76 | MET (0.53) | METPDE3BPDE3ACYP2C9PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966075-A1 | CERTAIN TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND THEIR USE IN THE TREATMENT OF CANCER. | Hutchison Medipharma Limited (CN) | 2016-01-13 | — | — | EP | disclosed |