Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.36 |
| ▸ | KDR | P35968 | 9/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16882542 | 0.85 | MET (0.46) | METFGFR1FGFR3KDRPDE3B | |
| SCHEMBL16882496 | 0.83 | MET (0.45) | METFGFR1FGFR3KDRPDE3B | |
| SCHEMBL12689736 | 0.81 | MET (0.66) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL17425935 | 0.80 | MET (0.48) | METFGFR1FGFR3KDRPDE3B | |
| SCHEMBL21167668 | 0.78 | CSF1R (0.41) | METFGFR1FGFR3KDRFGFR2 | |
| SCHEMBL21167664 | 0.77 | EGFR (0.40) | METFGFR1FGFR3KDRFGFR2 | |
| SCHEMBL16882492 | 0.75 | MET (0.53) | METFGFR1FGFR3KDRPDE3B | |
| SCHEMBL19261423 | 0.73 | MET (0.65) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL16587106 | 0.73 | MET (0.62) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591133 | 0.73 | MET (0.47) | METFGFR1FGFR3KDRPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |