Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743245 | 0.94 | SCN9A (1.00) | SCN9AFPR2 | |
| SCHEMBL16146574 | 0.94 | SCN9A (1.00) | SCN9AFPR2 | |
| SCHEMBL17427873 | 0.90 | SCN9A (0.91) | SCN9AFPR2 | |
| SCHEMBL19167175 | 0.90 | SCN9A (0.85) | SCN9AFPR2 | |
| SCHEMBL14743095 | 0.88 | SCN9A (1.00) | SCN9AFPR2 | |
| SCHEMBL14743092 | 0.88 | SCN9A (1.00) | SCN9AFPR2 | |
| SCHEMBL14754534 | 0.88 | FPR2 (0.85) | SCN9AFPR2 | |
| SCHEMBL14746256 | 0.88 | SCN9A (1.00) | SCN9AFPR2 | |
| SCHEMBL14743555 | 0.87 | FPR2 (1.00) | SCN9AFPR2 | |
| SCHEMBL14754524 | 0.87 | FPR2 (0.80) | SCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637458-B2 | Pyrimidine carboxamides as sodium channel blockers | PURDUE PHARMA L.P. | 2017-05-02 | — | — | US | disclosed |
| US-20160009659-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009659-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | CACNA1A, TRPV1, TRPA1 | SCN9A 86/4885FPR2 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.