Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 9/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17429734 | 1.00 | ACLY (0.34) | ACLYCYP19A1EGFRCCR2CYP2A6 | |
| SCHEMBL903682 | 0.92 | ACLY (0.34) | ACLYCYP19A1 | |
| SCHEMBL17429553 | 0.92 | ACLY (0.34) | ACLYCYP19A1 | |
| SCHEMBL18957720 | 0.92 | MAOB (0.40) | ACLYCYP19A1 | |
| SCHEMBL18957722 | 0.92 | MAOB (0.40) | ACLYCYP19A1 | |
| SCHEMBL903686 | 0.92 | ACLY (0.31) | ACLYCYP19A1 | |
| SCHEMBL903685 | 0.92 | ACLY (0.34) | ACLYCYP19A1 | |
| SCHEMBL903687 | 0.92 | ACLY (0.31) | ACLYCYP19A1 | |
| SCHEMBL17429555 | 0.82 | CYP19A1 (0.33) | CYP19A1CYP2A6 | |
| SCHEMBL19318923 | 0.80 | PIK3CA (0.31) | ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10457690-B2 | Process for preparing substituted tetracyclic heterocycle compounds | MERCK SHARP & DOHME CORP. (US) | 2019-10-29 | — | — | US | disclosed |
| US-10202401-B2 | Process for making tetracyclic heterocycle compounds | MSD R&D CN CO., LTD (CN) | 2019-02-12 | — | — | US | disclosed |
| US-20180179223-A1 | PROCESS FOR PREPARING SUBSTITUTED TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179223-A1 | PROCESS FOR PREPARING SUBSTITUTED TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MSD R&D (CHINA) CO., LTD (CN) | 2017-06-15 | — | — | US | disclosed |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MSD R&D (CHINA) CO., LTD (CN) | 2017-06-15 | — | — | US | disclosed |
| WO-2016196932-A1 | PROCESS FOR PREPARING SUBSTITUTED TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016004899-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10457690-B2 | Process for preparing substituted tetracyclic heterocycle compounds | ABL1, GTF3C5, TPI1 | ACLY 1201/4885CYP19A1 350/4885EGFR 1911/4885 |
| US-10202401-B2 | Process for making tetracyclic heterocycle compounds | CYP1B1, CYP1A2, CYP2F1 | ACLY 1087/4885CYP19A1 54/4885EGFR 1508/4885 |
| US-20180179223-A1 | PROCESS FOR PREPARING SUBSTITUTED TETRACYCLIC HETEROCYCLE COMPOUNDS | ABL1, GTF3C5, TPI1 | ACLY 1201/4885CYP19A1 350/4885EGFR 1911/4885 |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | CYP1A2, CYP3A5, CYP1B1 | ACLY 1184/4885CYP19A1 48/4885EGFR 1342/4885 |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | CYP1B1, CYP1A2, CYP2F1 | ACLY 1087/4885CYP19A1 54/4885EGFR 1508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.