TPI1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Phosphoglycolohydroxamate (SCHEMBL4309631)	1.00	2/20
SCHEMBL5485133	0.56	2/20
Phosphoglycolic Acid (SCHEMBL5586781)	0.52	2/20
SCHEMBL43277	0.50	2/20
SCHEMBL50365	0.50	2/20
SCHEMBL2474974	0.50	2/20
SCHEMBL811703	0.43	2/20
SCHEMBL6514945	0.42	2/20
SCHEMBL4456829	0.41	2/20
SCHEMBL26828	0.41	2/20
Alpha-Ketoglutaric Acid (SCHEMBL2030659)	0.41	2/20
SCHEMBL1650937	0.40	2/20
SCHEMBL3429625	0.40	2/20
SCHEMBL4360429	0.38	2/20
SCHEMBL1684262	0.37	2/20
SCHEMBL3429341	0.36	2/20
SCHEMBL3264608	0.35	2/20
Water (SCHEMBL6908198)	0.33	2/20
SCHEMBL7038891	0.33	2/20
SCHEMBL6653137	0.32	2/20

Clinical trials — most relevant to TPI1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia	PHASE3	COMPLETED
A Phase II Study of Capecitabine and Docetaxel in Previously Untreated Advanced Non-Small Cell Lung Cancer Patients	PHASE2	COMPLETED
A Phase II Study of TX Regimen as First-line Treatment for Asian Elderly Patients With Advanced Adenocarcinoma of Lung	PHASE2	COMPLETED
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma	PHASE1/PHASE2	RECRUITING
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma	PHASE1/PHASE2	RECRUITING
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer	PHASE2	UNKNOWN
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
MNGIE Natural History Study	nan	RECRUITING
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism	nan	NOT_YET_RECRUITING
Circadian Brown Adipose Tissue Metabolism	nan	COMPLETED
Evaluation of Thymidine Kinase Activity in the Serum of Patients With Solid Tumors	nan	UNKNOWN
Natural History of GACI With or Without ARHR2 or PXE	nan	UNKNOWN
Genetic Study of Sitosterolemia	nan	COMPLETED
The Role of TBC1D4 in Exercise- and Insulin-induced Glucose Metabolism in Human Skeletal Muscle	nan	COMPLETED
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Tamoxifen Pharmacogenetics in Asian Breast Cancer Women	nan	UNKNOWN
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Primary Hyperoxaluria Mutation Genotyping	nan	COMPLETED
Studying Phosphorus Metabolism	nan	COMPLETED
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment	nan	UNKNOWN
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Exome Sequencing for Atypical Femoral Fractures	nan	COMPLETED
United States Hypophosphatasia Molecular Research Center	nan	COMPLETED
The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a TPI1 binder may also engage these)

Protein	Name	Similarity
P60175	—	1.000	P60175 →
Q5E956	—	1.000	Q5E956 →
Q60HC9	—	1.000	Q60HC9 →
P54714	—	1.000	P54714 →
P15426	—	1.000	P15426 →
P00939	—	1.000	P00939 →
Q5R928	—	1.000	Q5R928 →
P17751	—	1.000	P17751 →
Q90XG0	—	1.000	Q90XG0 →
B0BM40	—	1.000	B0BM40 →
Q2QD07	—	1.000	Q2QD07 →
Q29371	—	1.000	Q29371 →
Q7ZWN5	—	0.999	Q7ZWN5 →
P86216	—	0.999	P86216 →
P00940	—	0.999	P00940 →
P48500	—	0.998	P48500 →
Q1MTI4	—	0.997	Q1MTI4 →
Q9HGY8	—	0.995	Q9HGY8 →
P30741	—	0.991	P30741 →
P29613	—	0.990	P29613 →
Q9GTX8	—	0.989	Q9GTX8 →
P92119	—	0.989	P92119 →
P82204	—	0.989	P82204 →
P91895	—	0.988	P91895 →
Q589R5	—	0.987	Q589R5 →
Q10657	—	0.987	Q10657 →
P04828	—	0.987	P04828 →
O77458	—	0.987	O77458 →
Q7JNS1	—	0.987	Q7JNS1 →
Q6BMB8	—	0.986	Q6BMB8 →