Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365496 | 0.85 | KEAP1 (0.50) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL16041940 | 0.82 | KEAP1 (0.54) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL2578143 | 0.80 | CXCL8 (0.57) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL29497752 | 0.80 | CXCL8 (0.57) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL3825211 | 0.79 | POLQ (0.41) | MAPTCASP1SMN1; SMN2MEN1SLC22A1 | |
| SCHEMBL3141863 | 0.78 | HIF1A (0.61) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL868684 | 0.78 | KEAP1 (0.51) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| Hydrochloric Acid SCHEMBL1373062 | 0.78 | CXCL8 (0.55) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL1614038 | 0.77 | KEAP1 (0.50) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL6950315 | 0.77 | KEAP1 (0.50) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202401-B2 | Process for making tetracyclic heterocycle compounds | MSD R&D CN CO., LTD (CN) | 2019-02-12 | — | — | US | disclosed |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MSD R&D (CHINA) CO., LTD (CN) | 2017-06-15 | — | — | US | disclosed |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MSD R&D (CHINA) CO., LTD (CN) | 2017-06-15 | — | — | US | disclosed |
| WO-2016004899-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202401-B2 | Process for making tetracyclic heterocycle compounds | CYP1B1, CYP1A2, CYP2F1 | KEAP1 855/4885NFE2L2 1225/4885CXCL8 3424/4885 |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | CYP1A2, CYP3A5, CYP1B1 | KEAP1 770/4885NFE2L2 1355/4885CXCL8 3385/4885 |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | CYP1B1, CYP1A2, CYP2F1 | KEAP1 855/4885NFE2L2 1225/4885CXCL8 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.