Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 4/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16114415 | 0.92 | PDE10A (0.40) | PDE10AEGLN1DYRK1AACVR2ATGFBR2 | |
| SCHEMBL16114251 | 0.89 | AAK1 (0.33) | PDE10AEGLN1DYRK1AAAK1ACACB | |
| SCHEMBL16114112 | 0.88 | PTGES (0.36) | PDE10ADYRK1APTGS2ACVR2ATGFBR2 | |
| SCHEMBL16113421 | 0.79 | PDE10A (0.40) | PDE10AEGLN1DYRK1APTGS2ACVR2A | |
| SCHEMBL17429766 | 0.78 | PDE4B (0.41) | DYRK1AMAPT | |
| SCHEMBL16114428 | 0.77 | P2RX7 (0.34) | PDE10AEGLN1 | |
| SCHEMBL16113426 | 0.76 | PTGES (0.37) | PDE10ADYRK1AACVR2ATGFBR2AAK1 | |
| SCHEMBL20083196 | 0.76 | PDE10A (0.39) | PDE10AEGLN1PTGS2PTGER2ACACB | |
| SCHEMBL16113412 | 0.75 | PDE10A (0.38) | PDE10AEGLN1DYRK1AACVR2ATGFBR2 | |
| SCHEMBL16113538 | 0.75 | DYRK1A (0.38) | PDE10AEGLN1DYRK1AACVR2ATGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160009691-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | DART NEUROSCIENCE, LLC | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009691-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4D | PDE10A 17/4885EGLN1 3289/4885DYRK1A 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.