Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30368099 | 1.00 | CYP2A6 (0.56) | CYP2A6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL31556857 | 0.78 | ATM (0.38) | CYP2A6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL21623948 | 0.78 | ATM (0.38) | CYP2A6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30402035 | 0.77 | RAB9A (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL240423 | 0.77 | RAB9A (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11252868 | 0.77 | CYP2A6 (0.52) | CYP2A6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29818023 | 0.77 | CYP2A6 (0.55) | CYP2A6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL16826055 | 0.77 | CYP2A6 (0.55) | CYP2A6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13750550 | 0.77 | CYP2A6 (0.58) | CYP2A6MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30948178 | 0.77 | MAPT (0.49) | CYP2A6MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115872976-B | Quinoline derivative, pharmaceutical composition containing quinoline derivative and application of pharmaceutical composition | 中国药科大学 | 2024-05-14 | — | — | CN | disclosed |
| CN-115872976-A | Quinoline derivative, pharmaceutical composition containing quinoline derivative and application of quinoline derivative | 中国药科大学 | 2023-03-31 | — | — | CN | disclosed |
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| US-9695175-B2 | Highly selective c-Met inhibitors as anticancer agents | CB THERAPEUTICS INC. (KY) | 2017-07-04 | — | — | US | disclosed |
| US-9695175-B2 | Highly selective c-Met inhibitors as anticancer agents | CB THERAPEUTICS INC. (KY) | 2017-07-04 | — | — | US | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |
| US-20150218171-A1 | HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS | APOLLOMICS INC. | 2015-08-06 | — | — | US | disclosed |
| US-20150218171-A1 | HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS | APOLLOMICS INC. | 2015-08-06 | — | — | US | disclosed |
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007003604-A2 | HISTS1MINE H3 RECEPTOR ANTAGONISTS | NOVO NORDISK A/S (DK) | 2007-01-11 | — | — | WO | disclosed |
| US-4590194-A | 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their cardiotonic use | STERLING DRUG INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4569934-A | ANTIANXIETY AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-02-11 | — | — | US | disclosed |
| EP-0029103-B1 | 6- AND 8-HETEROARYL-1,2,4-TRIAZOLO(4,3-B)PYRIDAZINES | AMERICAN CYANAMID COMPANY (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4354026-A | 3-Chloro-6-(pyridinyl)-pyridazines | STERLING DRUG INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4304775-A | 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| EP-0029103-A1 | 6- and 8-Heteroaryl-1,2,4-triazolo(4,3-b)pyridazines | AMERICAN CYANAMID COMPANY (US) | 1981-05-27 | — | — | EP | disclosed |
| US-4260756-A | TRANQUILIZERS | AMERICAN CYANAMID COMPANY (US) | 1981-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218171-A1 | HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS | MET, MYC, HGFAC | CYP2A6 4419/4885MAPT 3574/4885MEN1 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.