Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2694589 | 0.84 | JAK3 (0.70) | AURKARPS6KB1AURKBSIRT2JAK2 | |
| SCHEMBL2729346 | 0.82 | ROCK1 (0.47) | AURKARPS6KB1SIRT2SYK | |
| SCHEMBL2716084 | 0.81 | SIRT2 (0.52) | AURKARPS6KB1AURKBSIRT2JAK2 | |
| SCHEMBL2696155 | 0.74 | JAK3 (0.73) | AURKARPS6KB1SIRT2JAK2JAK1 | |
| SCHEMBL2481086 | 0.74 | JAK3 (0.76) | SIRT2JAK2JAK1JAK3TYK2 | |
| SCHEMBL17434737 | 0.74 | MAPT (0.44) | MAPTMEN1ALDH1A1POLBKMT2A | |
| SCHEMBL17088518 | 0.73 | JAK3 (0.57) | AURKARPS6KB1JAK2JAK1JAK3 | |
| SCHEMBL21167727 | 0.72 | ROCK1 (0.42) | AURKARPS6KB1AURKBMAPTMEN1 | |
| SCHEMBL17150843 | 0.71 | SYK (0.51) | AURKARPS6KB1AURKBMAPTSYK | |
| SCHEMBL21167726 | 0.71 | SYK (0.40) | AURKARPS6KB1AURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975027-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |