Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729349 | 0.84 | SYK (0.48) | MAPTMEN1KMT2AALDH1A1HCAR3 | |
| SCHEMBL2716087 | 0.82 | JAK1 (0.48) | MAPTMEN1KMT2AHCAR3HDAC3 | |
| SCHEMBL2694589 | 0.76 | JAK3 (0.70) | — | |
| SCHEMBL17434736 | 0.74 | AURKA (0.54) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL3722314 | 0.72 | HDAC3 (0.51) | MAPTMEN1KMT2AHDAC6MAPK1 | |
| SCHEMBL11567546 | 0.72 | HCAR3 (0.65) | MAPTMEN1KMT2AHCAR3MAPK1 | |
| SCHEMBL13569070 | 0.71 | PRKACA (0.54) | MAPTMEN1KMT2AALDH1A1VNN1 | |
| SCHEMBL3656971 | 0.70 | SYK (0.55) | MAPTMEN1KMT2ASYKMAPK1 | |
| SCHEMBL3715739 | 0.68 | HDAC3 (0.51) | HDAC6VNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL29006697 | 0.68 | PLAU (0.68) | MEN1KMT2AALDH1A1POLBVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975027-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |