Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17434736 | 0.82 | AURKA (0.54) | SIRT2SYKAURKARPS6KB1 | |
| SCHEMBL2729349 | 0.76 | SYK (0.48) | ROCK1ROCK2PRKACAPRKCDDYRK1A | |
| SCHEMBL2694589 | 0.75 | JAK3 (0.70) | SIRT2AURKARPS6KB1 | |
| SCHEMBL18616287 | 0.74 | AURKA (0.53) | ROCK1SYKAURKA | |
| SCHEMBL763449 | 0.72 | SYK (0.63) | SYK | |
| SCHEMBL10136785 | 0.71 | PIM1 (0.66) | SYKAURKARPS6KB1 | |
| SCHEMBL3455091 | 0.70 | SYK (0.61) | ROCK1ROCK2PRKACAPRKCDDYRK1A | |
| SCHEMBL7448597 | 0.70 | CHEK1 (0.50) | SYKCHEK1CHEK2AURKARPS6KB1 | |
| SCHEMBL3460612 | 0.69 | TP53 (0.54) | CHEK1CHEK2 | |
| SCHEMBL30938023 | 0.69 | PARP1 (0.65) | CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |