Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31469634 | 1.00 | GUCY1A1 (0.34) | GUCY1A1GUCY1B1CNR2MAT2A | |
| SCHEMBL18982428 | 0.92 | GUCY1A1 (0.40) | GUCY1A1GUCY1B1 | |
| SCHEMBL14776684 | 0.90 | PDE5A (0.35) | — | |
| SCHEMBL31469713 | 0.86 | — | — | |
| SCHEMBL31469705 | 0.83 | — | — | |
| SCHEMBL31018698 | 0.80 | L3MBTL1 (0.37) | GUCY1A1GUCY1B1CNR2MAT2A | |
| SCHEMBL31469661 | 0.79 | PTGER4 (0.33) | — | |
| SCHEMBL14776567 | 0.78 | ELANE (0.46) | MAT2A | |
| SCHEMBL31469623 | 0.78 | ENPP2 (0.31) | — | |
| SCHEMBL18982661 | 0.77 | GUCY1A1 (0.40) | GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575473-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2016-01-20 | — | — | EP | disclosed |