Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3687986 | 0.92 | OPRD1 (0.71) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL1257397 | 0.90 | OPRD1 (0.69) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL1894961 | 0.88 | OPRD1 (0.67) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL29389298 | 0.83 | OPRD1 (0.69) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL30340025 | 0.83 | OPRD1 (0.69) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL4705017 | 0.83 | OPRD1 (0.69) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| SCHEMBL3178079 | 0.83 | OPRD1 (0.60) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydrochloric Acid SCHEMBL3181605 | 0.82 | OPRD1 (0.59) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydromorphone SCHEMBL15399726 | 0.82 | OPRD1 (0.96) | OPRD1OPRM1OPRK1LMNAPDE4D | |
| Hydromorphone SCHEMBL6798556 | 0.82 | OPRD1 (1.00) | OPRD1OPRM1OPRK1LMNAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387577-A2 | NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS | Virginia Commonwealth University (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20110253334-A1 | TRIPLE PAPERMAKING FABRIC USE OF THE FABRIC AND PAPERMAKING METHOD | FELTRI MARONE S.P.A. (IT) | 2011-10-20 | — | — | US | disclosed |
| WO-2010083384-A9 | NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010083384-A2 | NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2010-07-22 | — | — | WO | disclosed |