SCHEMBL1743542

SCHEMBL1743542

O=CC(O)CC(O)CC(=O)O

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC22A6 Q4U2R8 1/20 0.55
GABRR1 P24046 2/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.41
AKR1B1 P15121 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
GPR84 Q9NQS5 4/20 0.38
HDAC2 Q92769 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
FOLH1 Q04609 1/20 0.33
HMGCR P04035 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13900287 1.00 SLC22A6 (0.55) SLC22A6GABRR1LMNAMAPTAKR1B1
SCHEMBL8169661 0.79
SCHEMBL14539493 0.79
SCHEMBL6442999 0.79
SCHEMBL4541049 0.79 SLC22A6 (0.52) SLC22A6GABRR1LMNAMAPTSMN1; SMN2
SCHEMBL15627217 0.79 SLC22A6 (0.52) SLC22A6GABRR1LMNAMAPTSMN1; SMN2
SCHEMBL6477452 0.79 SLC22A6 (0.52) SLC22A6GABRR1LMNAMAPTSMN1; SMN2
SCHEMBL15627216 0.79 SLC22A6 (0.52) SLC22A6GABRR1LMNAMAPTSMN1; SMN2
SCHEMBL15627215 0.79 SLC22A6 (0.52) SLC22A6GABRR1LMNAMAPTSMN1; SMN2
SCHEMBL356625 0.79 SLC22A6 (0.52) SLC22A6GABRR1LMNAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3141544-B1 PREPARATION METHOD FOR CHIRAL INTERMEDIATE FOR USE IN STATINS ASYMCHEM LABORATORIES (TIANJIN) CO LTD (CN) 2018-02-07 EP disclosed
EP-2752407-B1 Crystalline rosuvastatin calcium trihydrate KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) 2015-09-23 EP disclosed
CN-102282136-B Process for the preparation of rosuvastatin KRKA TOVARNA ZDRAVIL D D NOVO 2014-12-17 CN disclosed
EP-2752407-A1 Crystalline rosuvastatin calcium trihydrate Krka Tovarna Zdravil, D.D., Novo Mesto (SI) 2014-07-09 EP disclosed
EP-2387566-B1 PROCESS FOR THE PREPARATION OF ROSUVASTATIN KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) 2014-05-07 EP disclosed
EP-2387566-A1 PROCESS FOR THE PREPARATION OF ROSUVASTATIN KRKA, tovarna zdravil, d.d., Novo mesto (SI) 2011-11-23 EP disclosed
US-20110253932-A1 OPTICAL FUNCTIONAL FILM, RETARDATION FILM, COMPOSITION FOR FORMING OPTICAL FUNCTIONAL LAYER AND PRODUCING METHOD OF OPTICAL FUNCTIONAL FILM DAI NIPPON PRINTING CO., LTD. (JP) 2011-10-20 US disclosed
WO-2010081861-A1 PROCESS FOR THE PREPARATION OF ROSUVASTATIN KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) 2010-07-22 WO disclosed
EP-0464817-B1 2,4-Dihydroxyadipic acid derivative KANEGAFUCHI CHEMICAL IND (JP) 1996-10-09 EP disclosed
EP-0361273-B1 7-Substituted derivatives of 3,5-dihydroxyhept-6-inoic acid, process for their preparation, their use as medicaments, and intermediates HOECHST AG (DE) 1994-03-23 EP disclosed
US-5214197-A 2,4-DIHYDROXYADIPIC ACID DERIVATIVE KANEGAFUCHI CHEMICAL INDUSTRY CO., LTD. (JP) 1993-05-25 US disclosed
WO-1992010503-A1 PROCESS FOR THE PREPARATION OF 3,5-DIHYDROXY 6-OXO HEXANOIC ACID RHONE-POULENC RORER S.A. (FR) 1992-06-25 WO disclosed
US-5091386-A Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-25 US disclosed
EP-0464817-A1 2,4-Dihydroxyadipic acid derivative Kanegafuchi Chemical Industry Co., Ltd. (JP) 1992-01-08 EP disclosed
EP-0361273-A2 7-Substituted derivatives of 3,5-dihydroxyhept-6-inoic acid, process for their preparation, their use as medicaments, and intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1990-04-04 EP disclosed