Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL162572 | 0.90 | LMNA (0.49) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL173260 | 0.89 | TP53 (0.52) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL163130 | 0.85 | SMO (0.58) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL406879 | 0.84 | CYP2C9 (0.56) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL408805 | 0.84 | CYP2C9 (0.56) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL163647 | 0.83 | KMT2A (0.54) | TP53LMNAMAPTKMT2ACYP2C9 | |
| SCHEMBL161688 | 0.81 | DGAT1 (0.51) | TP53LMNAMAPTKMT2ANPC1 | |
| SCHEMBL174036 | 0.80 | CA12 (0.52) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL161847 | 0.79 | NPC1 (0.49) | TP53LMNAMAPTPOLBKMT2A | |
| SCHEMBL161754 | 0.78 | DGAT1 (0.57) | TP53LMNAMAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |