Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 17/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17438831 | 0.92 | OPRL1 (0.67) | OPRL1OPRM1HRH3OPRK1 | |
| SCHEMBL17439133 | 0.90 | OPRL1 (0.71) | OPRL1OPRM1HRH3OPRK1 | |
| SCHEMBL17439058 | 0.89 | OPRL1 (0.61) | OPRL1OPRM1HRH3OPRK1 | |
| SCHEMBL17438982 | 0.84 | OPRL1 (0.82) | OPRL1OPRM1 | |
| SCHEMBL17438695 | 0.83 | OPRM1 (0.53) | OPRL1OPRM1HRH3EPHX2ITGB3 | |
| SCHEMBL17438986 | 0.80 | OPRL1 (0.76) | OPRL1OPRM1 | |
| SCHEMBL17439016 | 0.80 | OPRM1 (0.71) | OPRL1OPRM1OPRK1 | |
| SCHEMBL17444359 | 0.77 | OPRM1 (0.68) | OPRL1OPRM1HRH3OPRK1 | |
| SCHEMBL17438840 | 0.77 | OPRM1 (0.68) | OPRL1OPRM1OPRK1 | |
| SCHEMBL17439003 | 0.77 | OPRM1 (0.91) | OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2016-01-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | OPRL1, OPRD1, OPRM1 | OPRL1 1/4885OPRM1 3/4885HRH3 813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.