Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.39 |
| ▸ | GABRP | O00591 | 6/20 | 0.39 |
| ▸ | GABRD | O14764 | 6/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.39 |
| ▸ | GABRE | P78334 | 6/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17440047 | 0.78 | CHRM1 (0.56) | ALDH1A1SMN1; SMN2GAALMNAGABRA1 | |
| SCHEMBL17440127 | 0.73 | JAK2 (0.43) | ALDH1A1SMN1; SMN2LMNAGABRA1GABRG2 | |
| SCHEMBL17440090 | 0.73 | CHRM1 (0.70) | GABRA1CHRM1PDE2APDE11A | |
| SCHEMBL4536161 | 0.67 | TP53 (0.49) | ALDH1A1SMN1; SMN2LMNARAB9APOLB | |
| SCHEMBL26899199 | 0.67 | GABRA1 (0.55) | ALDH1A1SMN1; SMN2LMNAGABRA1GABRG2 | |
| SCHEMBL23012965 | 0.65 | RAB9A (0.41) | ALDH1A1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL29479837 | 0.65 | RAB9A (0.41) | ALDH1A1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL243257 | 0.65 | MAPT (0.50) | ALDH1A1SMN1; SMN2GAAGABRA1GABRG2 | |
| SCHEMBL21664174 | 0.65 | CYP1A2 (0.60) | ALDH1A1SMN1; SMN2GAALMNASYK | |
| SCHEMBL31434593 | 0.65 | SYK (0.36) | ALDH1A1SMN1; SMN2GAALMNASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016907-A1 | PYRIDINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | PFIZER INC. (US) | 2016-01-21 | — | — | US | disclosed |
| WO-2016009297-A1 | PYRIDINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | PFIZER INC. (US) | 2016-01-21 | — | — | WO | disclosed |
| WO-2016009297-A1 | PYRIDINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | PFIZER INC. (US) | 2016-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016907-A1 | PYRIDINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, CHRM2, CHRM4 | ALDH1A1 2224/4885SMN1; SMN2 1519/4885GAA 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.