Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20786960 | 0.80 | PTGS1 (0.42) | TRPM5ERBB2PTGS1PTGS2NR3C1 | |
| SCHEMBL3377324 | 0.77 | ERBB2 (0.43) | TRPM5ERBB2PTGS1PTGS2NR3C1 | |
| SCHEMBL30817517 | 0.73 | KMO (0.60) | KMOFGFR1FGFR4RECQLHTR2A | |
| SCHEMBL2543455 | 0.73 | RECQL (0.66) | KMOFGFR1FGFR4ERBB2RECQL | |
| SCHEMBL30694932 | 0.73 | RECQL (0.66) | KMOFGFR1FGFR4ERBB2RECQL | |
| SCHEMBL3375263 | 0.72 | GLS (0.58) | ERBB2PTGS1PTGS2EGFR | |
| SCHEMBL6181444 | 0.71 | KMO (0.59) | KMOFGFR1FGFR4HTR2AHTR2C | |
| SCHEMBL30381343 | 0.71 | KMO (0.59) | KMOFGFR1FGFR4HTR2AHTR2C | |
| SCHEMBL17673897 | 0.71 | KMO (0.62) | KMOFGFR1FGFR4RECQLHTR2A | |
| SCHEMBL17673818 | 0.70 | KMO (0.66) | KMOFGFR1FGFR4RECQLHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016011390-A1 | IRAK4 INHIBITING AGENTS | BIOGEN MA INC. (US) | 2016-01-21 | — | — | WO | disclosed |