Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.41 |
| ▸ | PCNA | P12004 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28514177 | 0.83 | FPR2 (0.49) | SMN1; SMN2TSHRNPC1HPGDRAB9A | |
| SCHEMBL5752656 | 0.81 | CYP3A4 (0.49) | SMN1; SMN2TSHRNPC1HPGDRAB9A | |
| SCHEMBL5754973 | 0.81 | CYP3A4 (0.49) | SMN1; SMN2TSHRNPC1HPGDRAB9A | |
| SCHEMBL29603779 | 0.81 | CYP3A4 (0.55) | SMN1; SMN2TSHRNPC1RAB9ACYP1A2 | |
| SCHEMBL8749524 | 0.81 | CYP3A4 (0.55) | SMN1; SMN2TSHRNPC1RAB9ACYP1A2 | |
| SCHEMBL31008760 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2TSHRNPC1HPGDRAB9A | |
| SCHEMBL27732754 | 0.80 | MMEL1 (0.50) | MMEL1CTSKMAPK1 | |
| SCHEMBL2550395 | 0.79 | ATM (0.48) | SMN1; SMN2TSHRTACR1PCNACTSK | |
| SCHEMBL2550398 | 0.79 | ATM (0.48) | SMN1; SMN2TSHRTACR1PCNACTSK | |
| SCHEMBL29937544 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1HPGDRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387570-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |