Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744162 | 1.00 | PPARG (0.38) | PPARGPPARAALDH1A1L3MBTL1PDE2A | |
| SCHEMBL1744160 | 1.00 | PPARG (0.38) | PPARGPPARAALDH1A1L3MBTL1PDE2A | |
| SCHEMBL1743782 | 0.88 | PRKCA (0.38) | PPARGPPARAALDH1A1L3MBTL1CES2 | |
| SCHEMBL1743778 | 0.88 | PRKCA (0.38) | PPARGPPARAALDH1A1L3MBTL1CES2 | |
| SCHEMBL1743781 | 0.88 | PRKCA (0.38) | PPARGPPARAALDH1A1L3MBTL1CES2 | |
| SCHEMBL1743817 | 0.87 | ALDH1A1 (0.38) | PPARGPPARAALDH1A1L3MBTL1CES2 | |
| SCHEMBL1743820 | 0.87 | ALDH1A1 (0.38) | PPARGPPARAALDH1A1L3MBTL1CES2 | |
| SCHEMBL1743821 | 0.87 | ALDH1A1 (0.38) | PPARGPPARAALDH1A1L3MBTL1CES2 | |
| SCHEMBL1595149 | 0.84 | PRKCA (0.41) | PPARGPPARAALDH1A1L3MBTL1CES2 | |
| SCHEMBL1595147 | 0.84 | PRKCA (0.41) | PPARGPPARAALDH1A1L3MBTL1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387570-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |