Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743314 | 0.81 | ACE (0.47) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL31276834 | 0.76 | ACE (0.47) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL12737917 | 0.75 | PPARA (0.51) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL2796961 | 0.75 | PPARA (0.51) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL29153672 | 0.74 | PPARA (0.46) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL5153113 | 0.74 | ACE (0.52) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL8257996 | 0.73 | IDO1 (0.44) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL7277748 | 0.73 | ACE (0.51) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL8650265 | 0.73 | PTPN1 (0.52) | PTPN1ACEPPARGPPARAITGB3 | |
| SCHEMBL31276777 | 0.73 | ACE (0.46) | PTPN1ACEPPARGPPARAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387570-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |