Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PPM1B | O75688 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29843978 | 0.80 | KMT2A (0.31) | KMT2AATM | |
| SCHEMBL29010374 | 0.77 | TSHR (0.31) | — | |
| SCHEMBL15958383 | 0.73 | — | — | |
| SCHEMBL15570447 | 0.73 | ALDH1A1 (0.40) | ALDH1A1PKMKMT2AATMSLC1A2 | |
| SCHEMBL1333228 | 0.70 | ALDH1A1 (0.56) | ALDH1A1CYP1A2PKMCYP2C19PPM1B | |
| SCHEMBL2804787 | 0.70 | CYP1A2 (0.38) | ALDH1A1CYP1A2PKMCYP2C19PPM1B | |
| SCHEMBL631270 | 0.70 | ALDH1A1 (0.56) | ALDH1A1CYP1A2PKMCYP2C19PPM1B | |
| SCHEMBL8510385 | 0.70 | CYP1A2 (0.38) | ALDH1A1CYP1A2PKMCYP2C19PPM1B | |
| SCHEMBL15958390 | 0.69 | TET2 (0.39) | CYP1A2CYP3A4HSD17B10SLC1A2FOLH1 | |
| SCHEMBL17442874 | 0.68 | ALDH1A1 (0.46) | ALDH1A1CYP1A2PKMCYP2C19PPM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11752211-B2 | Fatty acids and their use in conjugation to biomolecules | NOVARTIS AG (CH) | 2023-09-12 | — | — | US | disclosed |
| EP-3988170-A1 | FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES | Novartis AG (CH) | 2022-04-27 | — | — | EP | disclosed |
| US-20210000964-A1 | NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2021-01-07 | — | — | US | disclosed |
| EP-3736334-A1 | RNAI COMPOSITIONS TO TREAT APOC3-RELATED DISEASES | Arrowhead Pharmaceuticals, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| US-10786576-B2 | Fatty acids and their use in conjugation to biomolecules | NOVARTIS AG (CH) | 2020-09-29 | — | — | US | disclosed |
| EP-3169784-B1 | RNAI COMPOSITIONS TO TREAT APOC3-RELATED DISEASES | ARROWHEAD PHARMACEUTICALS INC (US) | 2020-06-10 | — | — | EP | disclosed |
| US-10588980-B2 | Fatty acids and their use in conjugation to biomolecules | NOVARTIS AG (CH) | 2020-03-17 | — | — | US | disclosed |
| US-20180326079-A1 | NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2018-11-15 | — | — | US | disclosed |
| EP-3169784-A1 | ORGANIC COMPOSITIONS TO TREAT APOC3-RELATED DISEASES | Arrowhead Pharmaceuticals, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |
| US-20160030585-A1 | NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES | NOVARTIS AG (CH) | 2016-02-04 | — | — | US | disclosed |
| WO-2016011123-A1 | ORGANIC COMPOSITIONS TO TREAT APOC3-RELATED DISEASES | ARROWHEAD RESEARCH CORPORATION (US) | 2016-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160030585-A1 | NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES | FABP1, FABP2, FABP3 | ALDH1A1 849/4885CYP1A2 1373/4885PKM 1041/4885 |
| US-11752211-B2 | Fatty acids and their use in conjugation to biomolecules | FABP1, FABP2, FABP3 | ALDH1A1 907/4885CYP1A2 1053/4885PKM 1150/4885 |
| US-20180326079-A1 | NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES | FABP1, FABP2, FABP3 | ALDH1A1 849/4885CYP1A2 1373/4885PKM 1041/4885 |
| US-10786576-B2 | Fatty acids and their use in conjugation to biomolecules | FABP1, FABP2, FABP3 | ALDH1A1 907/4885CYP1A2 1053/4885PKM 1150/4885 |
| US-10588980-B2 | Fatty acids and their use in conjugation to biomolecules | FABP1, FABP2, FABP3 | ALDH1A1 907/4885CYP1A2 1053/4885PKM 1150/4885 |
| US-20210000964-A1 | NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES | FABP1, FABP2, FABP3 | ALDH1A1 849/4885CYP1A2 1373/4885PKM 1041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.