Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | MMP2 | P08253 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 3/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17443316 | 0.87 | KMT2A (0.59) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL17443304 | 0.85 | F2 (0.54) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL17443311 | 0.85 | CA2 (0.54) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL17443297 | 0.85 | KMT2A (0.53) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL9805877 | 0.83 | KMT2A (0.62) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL9398531 | 0.83 | KMT2A (0.66) | CA2MMP2CA1MMP1MMP9 | |
| Alanine SCHEMBL10626258 | 0.80 | CA2 (0.55) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL6544644 | 0.80 | KMT2A (0.66) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL11077619 | 0.77 | KMT2A (0.57) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL11765302 | 0.76 | KMT2A (0.66) | CA2MMP2CA1MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016009306-A1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | LUPIN LIMITED (IN) | 2016-01-21 | — | — | WO | disclosed |