Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 10/20 | 0.36 |
| ▸ | GSK3B | P49841 | 8/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.36 |
| ▸ | SRC | P12931 | 11/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15377039 | 0.77 | KCNN3 (0.39) | KCNN3JAK2JAK1JAK3 | |
| SCHEMBL174796 | 0.77 | KCNN3 (0.39) | KCNN3JAK2JAK1JAK3 | |
| SCHEMBL255544 | 0.77 | KCNN3 (0.39) | KCNN3JAK2JAK1JAK3 | |
| SCHEMBL176223 | 0.75 | KCNN3 (0.41) | KCNN3JAK2JAK1JAK3ABL1 | |
| SCHEMBL163755 | 0.74 | MEN1 (0.38) | KCNN3JAK2JAK1JAK3SRC | |
| SCHEMBL12430593 | 0.65 | AURKA (0.73) | AURKAGSK3BAURKBSRCAURKC | |
| SCHEMBL174966 | 0.64 | AURKA (0.53) | AURKAGSK3BAURKBSRCAURKC | |
| SCHEMBL173477 | 0.64 | HTR6 (0.33) | KCNN3SRCFYNFLT3ABL1 | |
| SCHEMBL173973 | 0.64 | AURKA (0.59) | AURKAGSK3BAURKBSRCAURKC | |
| SCHEMBL174497 | 0.64 | TP53 (0.32) | KCNN3SRCFYNFLT3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-14 | — | — | US | disclosed |
| EP-2611809-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030924-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK3, JAK2, JAK1 | KCNN3 3369/4885JAK2 2/4885JAK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.