⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26253259 | 0.84 | FBP1 (0.33) | — | |
| SCHEMBL25769000 | 0.84 | FBP1 (0.33) | — | |
| SCHEMBL17445995 | 0.80 | — | — | |
| SCHEMBL25768995 | 0.79 | — | — | |
| SCHEMBL26253261 | 0.79 | — | — | |
| SCHEMBL13247417 | 0.77 | — | — | |
| SCHEMBL13882141 | 0.76 | FBP1 (0.33) | — | |
| SCHEMBL14414761 | 0.75 | — | — | |
| SCHEMBL18893455 | 0.75 | — | — | |
| SCHEMBL27282033 | 0.72 | SMPD1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170283806-A1 | KRAS NUCLEIC ACIDS AND USES THEREOF | AVIDITY BIOSCIENCES, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170281795-A1 | NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF | AVIDITY BIOSCIENCES, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170283795-A1 | PHOSPHATIDYLINOSITOL-3-KINASE NUCLEIC ACIDS AND USES THEREOF | AVIDITY BIOSCIENCES, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170283476-A1 | MYC NUCLEIC ACIDS AND USES THEREOF | AVIDITY BIOSCIENCES, INC. | 2017-10-05 | — | — | US | disclosed |
| US-9745577-B2 | Reducing intron retention | UNIVERSITY OF SOUTHAMPTON (GB) | 2017-08-29 | — | — | US | disclosed |
| US-9714422-B2 | Reducing intron retention | UNIVERSITY OF SOUTHAMPTON (GB) | 2017-07-25 | — | — | US | disclosed |
| US-20170101641-A1 | MODULATION OF GENE EXPRESSION AND SCREENING FOR DEREGULATED PROTEIN EXPRESSION | UNIVERSITY OF SOUTHAMPTON (GB) | 2017-04-13 | — | — | US | disclosed |
| US-20170029822-A1 | TREATMENT USING TRUNCATED TRK B AND TRK C ANTAGONISTS | OTONOMY, INC. | 2017-02-02 | — | — | US | disclosed |
| US-20170029823-A1 | TRUNCATED TRK B AND TRK C ANTAGONISTS AND USES THEREOF | SARAGOVI HORACIO URI (CA) | 2017-02-02 | — | — | US | disclosed |
| US-20160244762-A1 | REDUCING INTRON RETENTION | UNIVERSITY OF SOUTHAMPTON (GB) | 2016-08-25 | — | — | US | disclosed |
| US-20160209414-A1 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF BREAST CANCER | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION | 2016-07-21 | — | — | US | disclosed |
| US-20160017322-A1 | REDUCING INTRON RETENTION | UNIVERSITY OF SOUTHAMPTON (GB) | 2016-01-21 | — | — | US | disclosed |