Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 19/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17443886 | 1.00 | OPRM1 (0.39) | OPRM1OPRL1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL17443887 | 1.00 | OPRM1 (0.39) | OPRM1OPRL1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL17443879 | 0.89 | OPRM1 (0.50) | OPRM1OPRL1 | |
| SCHEMBL17443881 | 0.89 | OPRM1 (0.50) | OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL17444033 | 0.89 | OPRM1 (0.43) | OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL17444032 | 0.89 | OPRM1 (0.43) | OPRM1OPRL1 | |
| Trifluoroacetic Acid SCHEMBL17444194 | 0.84 | OPRM1 (0.48) | OPRM1OPRL1 | |
| Trifluoroacetic Acid SCHEMBL17444059 | 0.84 | OPRM1 (0.48) | OPRM1OPRL1 | |
| Trifluoroacetic Acid SCHEMBL20210987 | 0.84 | OPRM1 (0.48) | OPRM1OPRL1 | |
| SCHEMBL17447500 | 0.84 | OPRM1 (0.41) | OPRM1OPRL1ALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170210734-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2017-07-27 | — | — | US | disclosed |
| US-20170210734-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2017-07-27 | — | — | US | disclosed |
| WO-2016008582-A1 | SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2016-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210734-A1 | Substituted Azaspiro(4.5)Decane Derivatives | OPRL1, OPRM1, OPRD1 | OPRM1 2/4885OPRL1 1/4885ALDH1A1 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.