Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 15/20 | 0.51 |
| ▸ | BMP4 | P12644 | 4/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 8/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 8/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 7/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 6/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.46 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.46 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 4/20 | 0.45 |
| ▸ | FLT4 | P35916 | 3/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19123887 | 0.93 | ACVR1 (0.53) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL19123956 | 0.92 | ACVR1 (0.53) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL19110560 | 0.87 | ACVR1 (0.53) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL17442450 | 0.85 | ACVR1 (0.72) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL23988709 | 0.84 | ACVR1 (0.53) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL19123821 | 0.84 | ACVR1 (0.71) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL25471663 | 0.84 | ACVR1 (0.52) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL19123961 | 0.83 | ACVR1 (0.71) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL19123600 | 0.81 | ACVR1 (0.60) | ACVR1BMP4BMPR1BACVRL1BMPR1A | |
| SCHEMBL19123596 | 0.81 | ACVR1 (0.69) | ACVR1BMP4BMPR1BACVRL1BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170197968-A1 | Compositions and Methods for Inhibiting BMP | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-07-13 | — | — | US | disclosed |
| WO-2016011019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197968-A1 | Compositions and Methods for Inhibiting BMP | BMP1, BMP2, BMPR2 | ACVR1 12/4885BMP4 4/4885BMPR1B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.