Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | ULK1 | O75385 | 2/20 | 0.39 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.38 |
| ▸ | BMP4 | P12644 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17448594 | 0.87 | ACVR1 (0.47) | KDRBMPR1AACVR1KMT2AGAK | |
| SCHEMBL17442121 | 0.87 | PDE2A (0.48) | KDRBMPR1AACVR1KMT2AGAK | |
| SCHEMBL17448543 | 0.85 | KDR (0.40) | KDRBMPR1AACVR1KMT2AGAK | |
| SCHEMBL19110527 | 0.82 | KDR (0.54) | KDRBMPR1AACVR1KMT2AGAK | |
| SCHEMBL17448593 | 0.81 | KDR (0.51) | KDRBMPR1AACVR1PDE2AMKNK2 | |
| SCHEMBL17442233 | 0.80 | ACVR1 (0.55) | KDRBMPR1AACVR1KMT2AGAK | |
| SCHEMBL23988812 | 0.80 | KDR (0.58) | KDRBMPR1AACVR1KMT2AGAK | |
| SCHEMBL17448596 | 0.78 | ACVR1 (0.71) | KDRBMPR1AACVR1BMPR1BACVR2A | |
| SCHEMBL17448595 | 0.77 | PCSK9 (0.41) | RET | |
| SCHEMBL23988771 | 0.76 | KDR (0.47) | KDRBMPR1AACVR1KMT2AGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170197968-A1 | Compositions and Methods for Inhibiting BMP | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-07-13 | — | — | US | disclosed |
| WO-2016011019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197968-A1 | Compositions and Methods for Inhibiting BMP | BMP1, BMP2, BMPR2 | KDR 217/4885BMPR1A 7/4885ACVR1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.