SCHEMBL17450356

SCHEMBL17450356

CCc1cccc(/C=N/OCC2CC2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
NPC1 O15118 2/20 0.34
GAA P10253 1/20 0.34
RAB9A P51151 1/20 0.34
BACE1 P56817 1/20 0.34
THRB P10828 1/20 0.34
HPGD P15428 1/20 0.34
HDAC4 P56524 1/20 0.33
MEF2D Q14814 1/20 0.33
TLR4 O00206 1/20 0.33
TLR2 O60603 1/20 0.33
BCHE P06276 1/20 0.33
UNG P13051 1/20 0.33
MAPT P10636 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
LMNA P02545 1/20 0.32
G6PC1 P35575 1/20 0.32
SLC5A2 P31639 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13468548 0.82 NPC1 (0.50) ALDH1A1L3MBTL1SMN1; SMN2NPC1GAA
SCHEMBL17450353 0.82 MAOA (0.39) ALDH1A1SMN1; SMN2NPC1GAARAB9A
SCHEMBL13469226 0.82 SMN1; SMN2 (0.41) ALDH1A1L3MBTL1SMN1; SMN2NPC1GAA
SCHEMBL8459424 0.82 SMN1; SMN2 (0.41) ALDH1A1L3MBTL1SMN1; SMN2NPC1GAA
SCHEMBL15614337 0.79 ALDH1A1 (0.39) ALDH1A1L3MBTL1SMN1; SMN2NPC1GAA
SCHEMBL24130977 0.78 NPC1 (0.47) L3MBTL1SMN1; SMN2NPC1GAARAB9A
SCHEMBL13469230 0.77 SRC (0.47) ALDH1A1SMN1; SMN2NPC1GAAHDAC4
SCHEMBL8471405 0.77 SRC (0.47) ALDH1A1SMN1; SMN2NPC1GAAHDAC4
SCHEMBL13468449 0.72 NPC1 (0.44) ALDH1A1L3MBTL1SMN1; SMN2NPC1GAA
SCHEMBL18717017 0.71 NPC1 (0.39) ALDH1A1SMN1; SMN2NPC1GAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016008862-A1 SUBSTITUTED VINYL AND ALKYNYL CYANOCYCLOALKANOLS AND VINYL AND ALKYNYL CYANOHETEROCYCLOALKANOLS AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-01-21 WO disclosed