Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 4/20 | 1.00 |
| ▸ | SCN2B | O60939 | 1/20 | 0.83 |
| ▸ | SCN1A | P35498 | 1/20 | 0.83 |
| ▸ | SCN4A | P35499 | 1/20 | 0.83 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.83 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.83 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.83 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.83 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.83 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321513 | 0.94 | SCN9A (0.89) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| Pf-05089771 SCHEMBL29376793 | 0.91 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| Pf-05089771 SCHEMBL1095065 | 0.91 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| Pf-05089771 SCHEMBL31060533 | 0.91 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| SCHEMBL319970 | 0.91 | SCN9A (0.88) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| Trifluoroacetic Acid SCHEMBL14889980 | 0.88 | SCN9A (0.79) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| SCHEMBL1094748 | 0.88 | SCN9A (0.78) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| SCHEMBL31643102 | 0.88 | SCN9A (0.78) | SCN9ACYP2C9SCN5ASCN2BSCN1A | |
| SCHEMBL16531374 | 0.86 | SCN9A (1.00) | SCN9ACYP2C9SCN5A | |
| SCHEMBL16531653 | 0.83 | SCN9A (1.00) | SCN9ACYP2C9SCN5ASCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016009303-A1 | PHARMACEUTICAL COMBINATIONS COMPRISING GABAPENTIN OR PREGABALIN WITH NAV1.7 INHIBITORS | PFIZER INC. (US) | 2016-01-21 | — | — | WO | disclosed |