Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744463 | 0.82 | ALDH1A1 (0.53) | UTS2RALDH1A1CYP3A4HSD17B10MEN1 | |
| SCHEMBL1744803 | 0.81 | KDM4E (0.41) | ALDH1A1CYP1A2HSD17B10KDM4ETLR7 | |
| SCHEMBL1746872 | 0.81 | KDM4E (0.43) | ALDH1A1LMNAHSD17B10KDM4EPOLB | |
| SCHEMBL1746367 | 0.78 | GRM5 (0.41) | UTS2RALDH1A1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL1746870 | 0.78 | CYP2C19 (0.51) | HSD17B10MEN1KMT2ACYP2C19POLB | |
| SCHEMBL1746375 | 0.78 | UTS2R (0.46) | UTS2RALDH1A1LMNACYP1A2HSD17B10 | |
| SCHEMBL1255125 | 0.78 | UTS2R (0.48) | UTS2RLDHAPKMCACNA1BAPBA1 | |
| SCHEMBL1745116 | 0.76 | UTS2R (0.47) | UTS2RLDHAPKMCACNA1BAPBA1 | |
| SCHEMBL317692 | 0.75 | UTS2R (0.46) | UTS2RLDHAPKMCACNA1BAPBA1 | |
| SCHEMBL317693 | 0.75 | UTS2R (0.46) | UTS2RLDHAPKMCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385042-B1 | Prokineticin 1 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-25 | — | — | EP | disclosed |
| EP-1973886-B1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-27 | — | — | EP | disclosed |
| EP-2385042-A1 | Prokineticin 1 receptor antagonists | Janssen Pharmaceutica N.V. (BE) | 2011-11-09 | — | — | EP | disclosed |
| US-8039028-B2 | Use of an extract of the orchid Vanda coerulea as a skin hydrating agent | LVMH REACHERCHE (FR) | 2011-10-18 | — | — | US | disclosed |