Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 3/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1746367 | 0.86 | GRM5 (0.41) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL1744803 | 0.85 | KDM4E (0.41) | ALDH1A1KDM4EHPGDHSD17B10TLR7 | |
| SCHEMBL1746872 | 0.85 | KDM4E (0.43) | ALDH1A1KDM4EHPGDHSD17B10FDPS | |
| SCHEMBL1746375 | 0.82 | UTS2R (0.46) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL1746870 | 0.82 | CYP2C19 (0.51) | HSD17B10MEN1KMT2A | |
| SCHEMBL1745114 | 0.82 | UTS2R (0.46) | ALDH1A1KDM4EHSD17B10UTS2RTLR7 | |
| SCHEMBL1977303 | 0.77 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL6442879 | 0.77 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL1744376 | 0.76 | KDM4E (0.36) | ALDH1A1KDM4EHTTFDPSMEN1 | |
| SCHEMBL7464659 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385042-B1 | Prokineticin 1 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-25 | — | — | EP | disclosed |
| EP-1973886-B1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-27 | — | — | EP | disclosed |
| EP-2385042-A1 | Prokineticin 1 receptor antagonists | Janssen Pharmaceutica N.V. (BE) | 2011-11-09 | — | — | EP | disclosed |
| US-8039028-B2 | Use of an extract of the orchid Vanda coerulea as a skin hydrating agent | LVMH REACHERCHE (FR) | 2011-10-18 | — | — | US | disclosed |