SCHEMBL1745247

SCHEMBL1745247

COC(=O)CCc1ccc(OCc2ccc(OCc3ccccc3)cc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 8/20 0.72
FFAR4 Q5NUL3 4/20 0.72
NPC1 O15118 1/20 0.58
RAB9A P51151 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
AKR1B1 P15121 1/20 0.57
LTA4H P09960 2/20 0.56
MAOB P27338 1/20 0.56
EPHX2 P34913 1/20 0.56
POLB P06746 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
LTB4R Q15722 1/20 0.56
LTB4R2 Q9NPC1 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1747136 1.00 FFAR1 (0.72) FFAR1FFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL1745237 0.96 FFAR1 (0.70) FFAR1FFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL14305720 0.96 FFAR1 (0.67) FFAR1FFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL1744585 0.93 FFAR1 (0.74) FFAR1FFAR4
SCHEMBL1744673 0.93 FFAR1 (0.74) FFAR1FFAR4AKR1B1
SCHEMBL1746671 0.93 FFAR1 (0.74) FFAR1FFAR4
SCHEMBL1745369 0.92 FFAR1 (0.76) FFAR1FFAR4AKR1B1
SCHEMBL1860911 0.91 FFAR1 (0.64) FFAR1FFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL1747202 0.90 SMN1; SMN2 (0.67) FFAR1FFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL1745339 0.90 FFAR1 (0.62) FFAR1FFAR4AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885NPC1 1470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.