SCHEMBL17453495 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	P2RY2	P41231	3/20	0.38

▸	P2RY1	P47900	3/20	0.38

▸	P2RY11	Q96G91	1/20	0.38

▸	IMPDH2	P12268	2/20	0.38

▸	POLRMT	O00411	1/20	0.37

▸	P2RX1	P51575	3/20	0.35

▸	P2RX3	P56373	3/20	0.35

▸	P2RX2	Q9UBL9	2/20	0.35

▸	RNASEL	Q05823	2/20	0.35

▸	P2RX4	Q99571	2/20	0.35

▸	ENTPD1	P49961	1/20	0.34

▸	P2RX7	Q99572	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL17453498	0.92	P2RY2 (0.41)	P2RY2P2RY1P2RY11IMPDH2POLRMT
SCHEMBL19644602	0.86	P2RY1 (0.40)	P2RY2P2RY1P2RY11IMPDH2POLRMT
SCHEMBL19644584	0.82	POLRMT (0.54)	P2RY2P2RY1P2RY11IMPDH2POLRMT
SCHEMBL17453490	0.82	POLRMT (0.54)	P2RY2P2RY1P2RY11IMPDH2POLRMT
SCHEMBL17453492	0.82	POLRMT (0.54)	P2RY2P2RY1P2RY11IMPDH2POLRMT
SCHEMBL17453476	0.80	HIF1A (0.34)	—
SCHEMBL19644568	0.79	P2RY1 (0.41)	P2RY2P2RY1P2RY11POLRMTP2RX1
SCHEMBL16708510	0.76	POLRMT (0.61)	P2RY2P2RY1P2RY11POLRMTP2RX1
Phosphoric Acid SCHEMBL17453496	0.76	IRAK4 (0.32)	IMPDH2
SCHEMBL19962266	0.76	P2RY2 (0.39)	P2RY2P2RY1P2RY11POLRMTP2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20250270229-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES, INC.	2025-08-28	—	—	US	disclosed
US-20250042913-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES INC (US)	2025-02-06	—	—	US	disclosed
EP-4023650-A1	4'-SUBSTITUTED-FURO[3,2-D]PYRIMIDINE AND -PYRROLO[3,2- D]PYRIMIDINE DERIVATIVES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	Gilead Sciences, Inc. (US)	2022-07-06	—	—	EP	disclosed
US-20190194223-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES, INC.	2019-06-27	—	—	US	disclosed
US-10179794-B2	Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections	GILEAD SCIENCES, INC. (US)	2019-01-15	—	—	US	disclosed
US-20180072755-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES, INC.	2018-03-15	—	—	US	disclosed
US-20180072755-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES, INC.	2018-03-15	—	—	US	disclosed
US-9828388-B2	Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections	GILEAD SCIENCES, INC. (US)	2017-11-28	—	—	US	disclosed
WO-2016018697-A1	THIENO [3,2-D] PYRIMIDINE, FURO [3,2,D] PYRIMIDINE, AND PYRROLO [3,2-D] PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES, INC. (US)	2016-02-04	—	—	WO	disclosed
US-20160024107-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES, INC.	2016-01-28	—	—	US	disclosed
US-20160024107-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES, INC.	2016-01-28	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20160024107-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	DPYD, TYMS, TYMP	P2RY2 57/4885P2RY1 93/4885P2RY11 492/4885
US-10179794-B2	Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections	DPYD, TYMS, TYMP	P2RY2 57/4885P2RY1 93/4885P2RY11 492/4885
US-20250270229-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	DPYD, TYMS, TYMP	P2RY2 57/4885P2RY1 93/4885P2RY11 492/4885
US-20250042913-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	DPYD, TYMS, TYMP	P2RY2 57/4885P2RY1 93/4885P2RY11 492/4885
US-20180072755-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	DPYD, TYMS, TYMP	P2RY2 57/4885P2RY1 93/4885P2RY11 492/4885
US-20190194223-A1	THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	DPYD, TYMS, TYMP	P2RY2 57/4885P2RY1 93/4885P2RY11 492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.