Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.67 |
| ▸ | BACE1 | P56817 | 4/20 | 0.67 |
| ▸ | MAOB | P27338 | 2/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.58 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.57 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079051 | 1.00 | GSK3B (0.67) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL5947111 | 1.00 | GSK3B (0.67) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL5947430 | 0.95 | GSK3B (0.59) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL5947426 | 0.95 | GSK3B (0.59) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL13845317 | 0.86 | PPARG (0.49) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL2776601 | 0.85 | GSK3B (0.76) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL2776603 | 0.85 | GSK3B (0.76) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL8895796 | 0.85 | KDM4E (0.55) | GSK3BBACE1MAOBPPARGPPARA | |
| SCHEMBL8168849 | 0.85 | KDM4E (0.55) | GSK3BBACE1MAOBPPARGPPARA | |
| SCHEMBL19079050 | 0.84 | P4HTM (0.51) | GSK3BBACE1MAOBABCG2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385032-A1 | GPR40 Receptor function regulator | Takeda Pharmaceutical Company Limited (JP) | 2011-11-09 | — | — | EP | disclosed |
| US-7960369-B2 | Receptor function regulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-14 | — | — | US | disclosed |
| US-7456218-B2 | 3-(4-benzyloxyphenyl) propanoic acid derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-25 | — | — | US | disclosed |
| US-7456218-B2 | 3-(4-benzyloxyphenyl) propanoic acid derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-25 | — | — | US | disclosed |
| US-20070149608-A1 | 3-(4-Benzyloxyphenyl) propanoic acid derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-28 | — | — | US | disclosed |
| US-20070149608-A1 | 3-(4-Benzyloxyphenyl) propanoic acid derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-28 | — | — | US | disclosed |
| US-20060135613-A1 | Carboxamides derivatives | BAYER HEALTHCARE AG (DE) | 2006-06-22 | — | — | US | disclosed |
| CN-1735408-A | Receptor function controlling agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-02-15 | — | — | CN | disclosed |
| EP-1515942-A1 | CARBOXAMIDES DERIVATIVES | Bayer HealthCare AG (DE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003106403-A1 | CARBOXAMIDES DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135613-A1 | Carboxamides derivatives | BPHL, HRH2, HRH4 | GSK3B 4456/4885BACE1 1566/4885MAOB 2795/4885 |
| US-20070149608-A1 | 3-(4-Benzyloxyphenyl) propanoic acid derivatives | GPR119, GPR55, GLP1R | GSK3B 4375/4885BACE1 2100/4885MAOB 4637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.