Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17459834 | 0.88 | FOLH1 (0.56) | FOLH1GRM2GRM3MRGPRX4ALDH1A1 | |
| SCHEMBL27760814 | 0.86 | FOLH1 (0.58) | FOLH1GRM2GRM3MRGPRX4ALDH1A1 | |
| SCHEMBL850937 | 0.82 | FOLH1 (0.53) | FOLH1GRM2GRM3MRGPRX4ALDH1A1 | |
| SCHEMBL371526 | 0.82 | FOLH1 (0.70) | FOLH1MRGPRX4CYP2D6CYP2C9HIF1A | |
| SCHEMBL848808 | 0.80 | FOLH1 (0.50) | FOLH1GRM2GRM3MRGPRX4ALDH1A1 | |
| SCHEMBL17215250 | 0.80 | FOLH1 (0.50) | FOLH1GRM2GRM3MRGPRX4ALDH1A1 | |
| SCHEMBL2278468 | 0.79 | FOLH1 (0.61) | FOLH1MRGPRX4ALDH1A1NPSR1CYP2D6 | |
| SCHEMBL30395109 | 0.78 | FOLH1 (0.66) | FOLH1MRGPRX4CYP2D6CYP2C9HIF1A | |
| SCHEMBL1817886 | 0.78 | FOLH1 (0.66) | FOLH1MRGPRX4CYP2D6CYP2C9HIF1A | |
| SCHEMBL16559877 | 0.78 | FOLH1 (0.66) | FOLH1MRGPRX4CYP2D6CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172211-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2017-05-31 | — | — | EP | disclosed |
| WO-2016011930-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-01-28 | — | — | WO | disclosed |