SCHEMBL1817886

SCHEMBL1817886

O=C(O)c1cccc(CCc2ccccc2)c1

nearest known ligand 0.66

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 3/20 0.66
DAO P14920 1/20 0.56
NR4A2 P43354 1/20 0.56
KMT2A Q03164 1/20 0.56
AKR1C3 P42330 1/20 0.55
KMO O15229 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
HIF1A Q16665 1/20 0.53
ANPEP P15144 1/20 0.53
ENPEP Q07075 1/20 0.53
MRGPRX4 Q96LA9 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30395109 1.00 FOLH1 (0.66) FOLH1DAONR4A2KMT2AAKR1C3
SCHEMBL371526 0.96 FOLH1 (0.70) FOLH1NR4A2KMT2ACYP2D6CYP2C9
SCHEMBL1296456 0.92 FOLH1 (0.61) FOLH1KMT2AAKR1C3CYP2D6CYP2C9
SCHEMBL1980273 0.92 FOLH1 (0.61) FOLH1NR4A2KMT2AAKR1C3KMO
Hydrochloric Acid SCHEMBL7138106 0.90 FOLH1 (0.59) FOLH1KMT2AAKR1C3CYP2D6CYP2C9
SCHEMBL27705270 0.89 FOLH1 (0.58) FOLH1DAOKMT2AAKR1C3CYP2D6
SCHEMBL1541757 0.88 FOLH1 (0.61) FOLH1NR4A2KMT2AAKR1C3CYP2D6
SCHEMBL16559877 0.88 FOLH1 (0.66) FOLH1NR4A2KMT2ACYP2D6CYP2C9
SCHEMBL27705284 0.87 FOLH1 (0.56) FOLH1DAONR4A2KMT2AAKR1C3
Benzoic Acid SCHEMBL4779307 0.87 DAO (0.70) FOLH1DAONR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107428923-B Modifier for resin and resin composition using same 株式会社ADEKA 2020-03-03 CN disclosed
US-10424745-B2 Organometallic complex, light-emitting element, display device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2019-09-24 US disclosed
US-20180212164-A1 Organometallic Complex, Light-Emitting Element, Display Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2018-07-26 US disclosed
EP-2743256-B1 CYCLOPROPANEAMINE COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2018-06-27 EP disclosed
EP-2496591-B1 ORGANOMETALLIC COMPLEX, LIGHT-EMITTING ELEMENT, DISPLAY DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LAB (JP) 2018-05-30 EP disclosed
EP-1763509-B1 ALPHA-HELICAL MIMETICS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2018-02-21 EP disclosed
EP-2150526-B1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE VTV THERAPEUTICS LLC (US) 2017-09-20 EP disclosed
US-9682925-B2 Cyclopropaneamine compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-06-20 US disclosed
CN-103842332-B Cyclopropylamine compound 武田药品工业株式会社 2016-08-17 CN disclosed
US-20160130215-A1 CYCLOPROPANEAMINE COMPOUND TAKEDA PHARMACEUTICAL (JP) 2016-05-12 US disclosed
EP-1763509-A1 ALPHA-HELICAL MIMETICS THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2007-03-21 EP disclosed
EP-1748046-A2 Inhibitors of histone deacetylase Methylgene, Inc. (CA) 2007-01-31 EP disclosed
EP-1748046-A2 Inhibitors of histone deacetylase Methylgene, Inc. (CA) 2007-01-31 EP disclosed
CN-1863768-A Prostaglandin analogs as agonists of the EP4 receptor HOFFMANN LA ROCHE (CH) 2006-11-15 CN disclosed
WO-2006002474-A1 ALPHA-HELICAL MIMETICS THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2006-01-12 WO disclosed
US-20050113450-A1 Antibacterial agents PHARMACIA & UPJOHN COMPANY 2005-05-26 US disclosed
WO-2004018414-A2 ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed
US-6541661-B1 For treating cell proliferative diseases and conditions METHYLGENE, INC. (CA) 2003-04-01 US disclosed
EP-1233958-A1 INHIBITORS OF HISTONE DEACETYLASE Methylgene, Inc. (CA) 2002-08-28 EP disclosed
WO-2001038322-A1 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2001-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050113450-A1 Antibacterial agents CLPP, SPOUT1, SAMHD1 FOLH1 1837/4885DAO 463/4885NR4A2 4642/4885
US-20160130215-A1 CYCLOPROPANEAMINE COMPOUND KDM1A, KDM1B, KDM3A FOLH1 838/4885DAO 579/4885NR4A2 2647/4885
US-10424745-B2 Organometallic complex, light-emitting element, display device, electronic device, and lighting device GRK1, CDKL1, ARL1 FOLH1 4437/4885DAO 1750/4885NR4A2 319/4885
US-20180212164-A1 Organometallic Complex, Light-Emitting Element, Display Device, Electronic Device, and Lighting Device GRK1, CDKL1, ARL1 FOLH1 4437/4885DAO 1750/4885NR4A2 319/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.