Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.45 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17460361 | 0.83 | MAPT (0.43) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17460404 | 0.80 | MAPT (0.53) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17460382 | 0.78 | POLB (0.47) | KDM4EALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL17460364 | 0.77 | PDE4B (0.50) | HPGDMAPTSMN1; SMN2LMNANPC1 | |
| SCHEMBL17460379 | 0.75 | PDE4B (0.51) | HPGDMAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL17460397 | 0.71 | KCNQ3 (0.48) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19148004 | 0.71 | MAPT (0.48) | KDM4EHPGDALDH1A1MAPTLMNA | |
| SCHEMBL28993013 | 0.71 | ATR (0.57) | — | |
| SCHEMBL13841949 | 0.70 | ALDH1A1 (0.53) | KDM4EHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL15748787 | 0.70 | MAPT (0.62) | KDM4EHPGDALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170204099-A1 | Pyrazolopyrimidine Compounds | PFIZER INC. (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170204099-A1 | Pyrazolopyrimidine Compounds | PFIZER INC. (US) | 2017-07-20 | — | — | US | disclosed |
| EP-3172210-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | Pfizer Inc (US) | 2017-05-31 | — | — | EP | disclosed |
| WO-2016012896-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2016-01-28 | — | — | WO | disclosed |
| WO-2016012896-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204099-A1 | Pyrazolopyrimidine Compounds | DPYD, QDPR, ABCG2 | KDM4E 2139/4885HPGD 1926/4885ALDH1A1 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.