Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 8/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27110045 | 0.89 | KCNQ3 (0.51) | ALDH1A1L3MBTL1APOBEC3AKCNQ3KCNQ2 | |
| SCHEMBL17460378 | 0.85 | PDE4A (0.50) | KCNQ3KCNQ2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17460380 | 0.85 | HPGD (0.49) | ALDH1A1APOBEC3AKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL17468540 | 0.85 | SMN1; SMN2 (0.49) | ALDH1A1L3MBTL1APOBEC3AKCNQ3KCNQ2 | |
| SCHEMBL17460381 | 0.83 | KCNQ3 (0.47) | ALDH1A1L3MBTL1APOBEC3AKCNQ3KCNQ2 | |
| SCHEMBL17460391 | 0.83 | L3MBTL1 (0.54) | ALDH1A1L3MBTL1KCNQ3KCNQ2GAA | |
| SCHEMBL17460404 | 0.82 | MAPT (0.53) | ALDH1A1APOBEC3AKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL17468714 | 0.82 | HPGD (0.52) | ALDH1A1APOBEC3AKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL17468713 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1APOBEC3AKCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL19147882 | 0.82 | SMN1; SMN2 (0.44) | ALDH1A1L3MBTL1APOBEC3AKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10131669-B2 | Pyrazolopyrimidine compounds | PFIZER INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-20170204099-A1 | Pyrazolopyrimidine Compounds | PFIZER INC. (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170204099-A1 | Pyrazolopyrimidine Compounds | PFIZER INC. (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170204099-A1 | Pyrazolopyrimidine Compounds | PFIZER INC. (US) | 2017-07-20 | — | — | US | disclosed |
| EP-3172210-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | Pfizer Inc (US) | 2017-05-31 | — | — | EP | disclosed |
| WO-2016012896-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2016-01-28 | — | — | WO | disclosed |
| WO-2016012896-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10131669-B2 | Pyrazolopyrimidine compounds | PDE4B, PDE4A, PDE7A | ALDH1A1 651/4885L3MBTL1 4144/4885APOBEC3A 2375/4885 |
| US-20170204099-A1 | Pyrazolopyrimidine Compounds | DPYD, QDPR, ABCG2 | ALDH1A1 381/4885L3MBTL1 4647/4885APOBEC3A 3427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.