Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | NOX1 | Q9Y5S8 | 7/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LPL | P06858 | 5/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13832944 | 0.85 | LPL (0.43) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL21392309 | 0.82 | LIPG (0.54) | LPLLIPG | |
| SCHEMBL28400845 | 0.82 | KDM1A (0.44) | ADRA2AADRA2BADRA2CCHRM3SLC6A2 | |
| SCHEMBL20114153 | 0.81 | LIPG (0.52) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL28585872 | 0.81 | PIM1 (0.43) | MEN1ADRA2AADRA2BADRA2CCHRM3 | |
| SCHEMBL203692 | 0.81 | LIPG (0.51) | LPLLIPG | |
| SCHEMBL20114185 | 0.80 | LPL (0.48) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL20114063 | 0.80 | LIPG (0.47) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL3476592 | 0.80 | HDAC6 (0.38) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL20114170 | 0.79 | LPL (0.37) | MAOANOX1L3MBTL1MEN1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-1926729-B1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110254413-A1 | CASING OF ELECTRONIC DEVICE AND MANUFACTURING METHOD THEREOF | ASUSTEK COMPUTER INC. (TW) | 2011-10-20 | — | — | US | disclosed |
| EP-2258703-A1 | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands | Abbott Laboratories (US) | 2010-12-08 | — | — | EP | disclosed |