Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 12/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | PPIB | P23284 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | PPIG | Q13427 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14061574 | 0.89 | DGAT1 (0.53) | DGAT1TDP2 | |
| SCHEMBL14061842 | 0.86 | DGAT1 (0.48) | DGAT1TDP2TNFPPIBPPIA | |
| SCHEMBL17211801 | 0.86 | SMN1; SMN2 (0.43) | LMNAALDH1A1PRKCZMAPTRAB9A | |
| SCHEMBL17211803 | 0.81 | TDP2 (0.44) | TDP2LMNAALDH1A1MEN1GAA | |
| SCHEMBL10341539 | 0.80 | SMN1; SMN2 (0.47) | DGAT1LMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14061946 | 0.80 | DGAT1 (0.57) | DGAT1 | |
| SCHEMBL14062046 | 0.80 | DGAT1 (0.46) | DGAT1TDP2 | |
| SCHEMBL14061731 | 0.78 | DGAT1 (0.44) | DGAT1TDP2 | |
| SCHEMBL14137211 | 0.78 | DGAT1 (0.44) | DGAT1TNFLMNANPC1RAB9A | |
| SCHEMBL15690595 | 0.77 | DGAT1 (0.43) | DGAT1TNFLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242929-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |