Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 16/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22189751 | 0.88 | AKT1 (0.48) | RIPK3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3355854 | 0.83 | MKNK1 (0.39) | MKNK1RIPK3PDE4APDE4BPDE4C | |
| SCHEMBL4710579 | 0.80 | MKNK1 (0.49) | MKNK1RIPK3PDE4APDE4BPDE4C | |
| SCHEMBL456971 | 0.74 | MKNK1 (0.37) | MKNK1RIPK3PDE4APDE4BPDE4C | |
| SCHEMBL22189658 | 0.74 | PDE4D (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL477190 | 0.73 | RIPK3 (0.46) | MKNK1RIPK3PDE4APDE4BPDE4C | |
| SCHEMBL1745964 | 0.72 | PDE4A (0.48) | MKNK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5801474 | 0.67 | MKNK1 (0.53) | MKNK1 | |
| SCHEMBL2068562 | 0.66 | PDE4B (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2066630 | 0.66 | CA1 (0.36) | MKNK1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385946-A1 | DERIVATIVES OF 6-CYCLOAMINO-2,3-DI-PYRIDINYL-IMIDAZO[1,2-B]-PYRIDAZINE, PREPARATION AND TUERAPEUTIC APPLICATION THEREOF | SANOFI (FR) | 2011-11-16 | — | — | EP | disclosed |
| US-8040450-B2 | Liquid crystal electro-optic device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2011-10-18 | — | — | US | disclosed |
| WO-2010070238-A1 | DERIVATIVES OF 6-CYCLOAMINO-2,3-DI-PYRIDINYL-IMIDAZO[1,2-B]-PYRIDAZINE, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2010-06-24 | — | — | WO | disclosed |